RBC-serology imusyn

Recombinant blood group antigens for serology

The detection of antibodies to blood group antigens is crucial in pre and posttransfusion testing to allow for adequate blood supply of patients requiring blood transfusions. In cases when e.g. antibody mixtures, autoantibodies or alloantibodies to high-prevalence blood group antigens are present, the clear identification could be problematic due to unspecific positive (false positive) or overlapping reactions in antibody screening. Recombinant blood group antigens (rBGA) by imusyn can specifically inhibit antibodies and therefore minimize the risk of incompatible blood transfusions.

Method

  • Preincubation of 2 μl rBGA with 25 μl patient serum: neutralization of specific red cell antibodies
  • Serum can be used for indirect antiglobulin test with conventional gel card systems (Grifols DG® Gel Coombs, Bio-Rad ID-Card LISS/Coombs)

rBGA Features & Advantages

  • Simple test procedure
  • Direct antibody identification
  • Antibody detection and identification in one step
  • Simple and fast detection and identification of alloantibodies to high-prevalence blood group antigens
  • Better resolution of antibody mixtures
  • Neutralization of clinically insignificant antibodies to high-prevalence antigens in pretransfusion cross-matching
  • Faster and safer treatment of immunized patients
  • Easy to implement in routine serology

Art. No. Name Description
004 010 001 Chido(a) vial à 300 µl
004 010 002 Knops(a)
vial à 300 µl
004 010 003 CROM/DAF vial à 300 µl
004 010 004 Dombrock(a) vial à 300 µl
004 010 005 Dombrock(b) vial à 300 µl
004 010 006 Duffy(a) vial à 300 µl
004 010 007 Duffy(b) vial à 300 µl
004 010 008 Kell-Kp(b)-Js(a) vial à 300 µl
004 010 009 Indian(b) vial à 300 µl
004 010 010 JMH vial à 300 µl
004 010 011 Cellano-Kp(b)-Js(a) vial à 300 µl
004 010 012 Lutheran(a) vial à 300 µl
004 010 013 Lutheran(b) vial à 300 µl
004 010 014 Landsteiner-Wiener(a) vial à 300 µl
004 010 015 Rodgers(a) vial à 300 µl
004 010 016 Scianna1 vial à 300 µl
004 010 017 Xg(a) vial à 300 µl
004 010 018 Cartwright(a) vial à 300 µl
* serological tested antigens - all relevant antigens on recombinant proteins are listed in the IFU

References
Seltsam A, Blasczyk R. Recombinant blood group proteins for use in antibody screening and identification tests. Curr Opin Hematol 2009:16:473-9.
Seltsam A, Wagner F, Lambert M, et al. Recombinant blood group proteins facilitate the detection of alloantibodies to highprevalence antigens and reveal underlying antibodies: results of an international study. Transfusion 2014;54:1823-30.
Seltsam A, Blasczyk R. Recombinant blood group proteins in clinical practice - from puzzling to binary antibody testing. ISBT Science Series 2016; 11:243-249.


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