Human Neutrophil Antigens (HNA) are glycoproteins expressed on the cell surface of neutrophil granulocytes. Alloimmune reactions against neutrophils can lead to a serious blood transfusion complication calles Transfusion Related Acute Lung Injury (TRALI).Furthermore during pregnancy an alloimmune reaction can be triggered bythe mother producing antibodies against the antigens of the HNS-system of the child. The transfer of these antibodies into the fetal circuit leads to the destruction of the neutrophil granulocytes (Neonatale ImmuneNeutropenia, NIN).
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