Antibody based drugs can disturb serological blood group testing since the examined antigens can be masked by the therapeutic antibodies. An anti-CD38 antibody for treatment of multiple myeloma shows a strong interference in the indirect antiglobulin test (IAT) where most of the reactions turn to unspecifically (wrong) positive. The time consuming standard technique using Dithiothreitol (DTT) counteracts the interference but has major drawbacks like destruction of Kel antigens or hemolysis. The imusyn DaraEx compound inhibits the agglutination effect of anti-CD38 in IAT without side effects.
Art. No. | Name | Description |
---|---|---|
RUO | Not for use in diagnostic procedures - USA and Canada | |
004 020 001 | DaraEx | Tube á 450 µl |
004 020 002 | DaraEx Positive Control, 450µl |
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